Tracer kinetics in biomedical research





Preface

The use of mathematical modeling techniques in biomedical research

is playing an increasingly important role as one seeks to understand the

physiopathology of disease processes. This includes not only understanding

mechanisms of physiological processes, but diagnosis and treatment.

In addition, its introduction in the study of genomics and proteomics is

key in understanding the functional characteristics of gene expression

and protein assembly and secretion. Finally, with the increasing com-

plexity and associated cost of drug development, modeling techniques

are being used to streamline the process.


We have worked in close collaboration with colleagues in biomedical

and pharmaceutical research for a number of years applying and refining

mathematical modeling techniques to a variety of problems. In addition,

we have worked in collaboration with colleagues in applied mathematics

and statistics to develop new algorithms to solve new sets of problems

as they emerge in our research efforts. Finally, we have worked with

colleagues in computer science to develop new software tools that bring

the power of mathematical modeling to a broad research community.

This books brings together much of what we have learned over the years,

and presents the material in a format that should be accessible both to

the novice reader and those desiring more detailed information about

specific techniques.


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