Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis
Preface
Although the technologies on chiral/enantiomer separation and stereoselective analysis
have matured in the past ca. 20 years, the development of new, even more advanced chiral
separation materials, mechanisms and methods still belong to the more challenging
tasks in separation science and analytical chemistry. An analysis of recent trends indicates that
capillary electrophoresis (CE) can show real advantages over
chromatographic methods in ultratrace chiral determination of biologically active ionogenic
compounds in complex matrices, including mostly biological ones. This is due to the
extremely high separation efficiency of CE, as well as numerous new chiral selectors
providing a wide range of selectivities for CE. Along with these tools, there are many
applicable in-capillary electro migration effects in CE (countercurrent migration,
stacking effects, etc.) enhancing significantly separability and, moreover, enabling effective
sample preparation (preconcentration, purification, analyte derivatization). Other possible on-line combinations of CE, such as column coupled CE-CE techniques
and implementation of nonelectrophoretic techniques (extraction, membrane filtration, flow injection, etc.) into CE, offer additional approaches for highly effective sample preparation and separation. Chiral CE matured to a highly flexible and compatible
technique enabling its hyphenation with powerful detection systems allows for extremely sensitive detection (e.g., laser induced fluorescence) and/or structural characterization of analytes (e.g., mass spectrometry). Within the last decade, more and less conventional analytical on-line approaches have been effectively utilized in this field, and their practical potentialities have been demonstrated in many application examples in the literature.
The scientific monograph provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
InTeOp -- 2012 -- ISBN: 9535106579 9789535106579 -- 205 pages -- PDF -- 15 MB
Download
*
Preface
Although the technologies on chiral/enantiomer separation and stereoselective analysis
have matured in the past ca. 20 years, the development of new, even more advanced chiral
separation materials, mechanisms and methods still belong to the more challenging
tasks in separation science and analytical chemistry. An analysis of recent trends indicates that
capillary electrophoresis (CE) can show real advantages over
chromatographic methods in ultratrace chiral determination of biologically active ionogenic
compounds in complex matrices, including mostly biological ones. This is due to the
extremely high separation efficiency of CE, as well as numerous new chiral selectors
providing a wide range of selectivities for CE. Along with these tools, there are many
applicable in-capillary electro migration effects in CE (countercurrent migration,
stacking effects, etc.) enhancing significantly separability and, moreover, enabling effective
sample preparation (preconcentration, purification, analyte derivatization). Other possible on-line combinations of CE, such as column coupled CE-CE techniques
and implementation of nonelectrophoretic techniques (extraction, membrane filtration, flow injection, etc.) into CE, offer additional approaches for highly effective sample preparation and separation. Chiral CE matured to a highly flexible and compatible
technique enabling its hyphenation with powerful detection systems allows for extremely sensitive detection (e.g., laser induced fluorescence) and/or structural characterization of analytes (e.g., mass spectrometry). Within the last decade, more and less conventional analytical on-line approaches have been effectively utilized in this field, and their practical potentialities have been demonstrated in many application examples in the literature.
The scientific monograph provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
InTeOp -- 2012 -- ISBN: 9535106579 9789535106579 -- 205 pages -- PDF -- 15 MB
Download
*