Nanomaterials for Biomedicine
Preface
This book results from the symposium “Nanomaterials for Biological,
Pharmaceutical and Biomedical Applications” held at the 240
th
Meeting in Boston, MA on August 22–26, 2010. The symposium was
sponsored by the ACS Division of Colloid and Surface Chemistry as part of its
continuing symposia series on nanoscience and nanotechnology. The symposium
included technical sessions devoted to synthesis of nanoparticles, biomolecular
functionalization of nanoparticles, nanoparticle for detection of biomolecules and
cells, applications of gold nanoparticles, applications of magnetic nanomaterials,
nanoparticle-cell interactions, polymer nanoparticles for drug delivery, and
nanoparticle applications in gene delivery, diagnostic imaging, molecular
diagnostics, therapeutics, etc. Over 90 papers were presented at this symposium,
and the book chapters represent a sampling of problems addressed.
The application of nanoparticles to biomedicine has become a distinct and
extremely active area of scientific and technological development over the last
ten years. A Web of Science keyword search reveals the dramatic increase in
the number of studies related to applications of nanoparticles for drug delivery
and imaging over the last decade, the correspondingly increasing investigations
of nanoparticle toxicity, and a growing interest in nanoparticles for combined
diagnostics and therapeutics. The entry for 2012 in Table 1 covers only the first
nine months and indicates that the growth in research publications continues at
the same rapid rate.
ACS National
The use of nanomaterials for biomedicine seeks to take advantage of the
size, shape, and large specific surface area characteristics that are intrinsic to
nanomaterials. The large enough volume of nanoparticles compared to the
molecular scale of typical drugs allows the nanoparticles to be carriers of a
large load of drugs or imaging agents. The large specific surface area of the
nanoparticles and our ability to functionalize and modify the surface properties
allows for many advantages to be derived from use of nanomaterials. Drugs
or imaging agents can be easily conjugated chemically to the nanoparticles
to improve the stability of the drug in the nanocarriers. Nanoparticles can
incorporate more than one kind of imaging or therapeutic agents, making them
potential multifunctional systems for both medical diagnosis and therapy. Specific
targeting of tissues and organs can be realized with multiple targeting agents
connected to the nanoparticle surface, providing strength of target binding as
well as high specificity for the target. Many methods of surface modification
have been developed to improve the circulation time of nanoparticles and to
prevent their uptake and removal by the reticuloendothelial system. The use of
nanomaterials as carriers is also stimulated by the potential for improved drug
stability, solubility, and bioavailability, improved pharmacokinetics, and reduced
immunogenicity.
This book results from the symposium Nanomaterials for Biological, Pharmaceutical and Biomedical Applications held at the 240th ACS National Meeting in Boston, MA on August 22-26, 2010. The symposium was sponsored by the ACS Division of Colloid and Surface Chemistry as part of its continuing symposia series on nanoscience and nanotechnology.
Published: 2013-03-22 -- ISBN: 0841227187 -- PDF -- 344 pages -- 18 MB
Download
*
Preface
This book results from the symposium “Nanomaterials for Biological,
Pharmaceutical and Biomedical Applications” held at the 240
th
Meeting in Boston, MA on August 22–26, 2010. The symposium was
sponsored by the ACS Division of Colloid and Surface Chemistry as part of its
continuing symposia series on nanoscience and nanotechnology. The symposium
included technical sessions devoted to synthesis of nanoparticles, biomolecular
functionalization of nanoparticles, nanoparticle for detection of biomolecules and
cells, applications of gold nanoparticles, applications of magnetic nanomaterials,
nanoparticle-cell interactions, polymer nanoparticles for drug delivery, and
nanoparticle applications in gene delivery, diagnostic imaging, molecular
diagnostics, therapeutics, etc. Over 90 papers were presented at this symposium,
and the book chapters represent a sampling of problems addressed.
The application of nanoparticles to biomedicine has become a distinct and
extremely active area of scientific and technological development over the last
ten years. A Web of Science keyword search reveals the dramatic increase in
the number of studies related to applications of nanoparticles for drug delivery
and imaging over the last decade, the correspondingly increasing investigations
of nanoparticle toxicity, and a growing interest in nanoparticles for combined
diagnostics and therapeutics. The entry for 2012 in Table 1 covers only the first
nine months and indicates that the growth in research publications continues at
the same rapid rate.
ACS National
The use of nanomaterials for biomedicine seeks to take advantage of the
size, shape, and large specific surface area characteristics that are intrinsic to
nanomaterials. The large enough volume of nanoparticles compared to the
molecular scale of typical drugs allows the nanoparticles to be carriers of a
large load of drugs or imaging agents. The large specific surface area of the
nanoparticles and our ability to functionalize and modify the surface properties
allows for many advantages to be derived from use of nanomaterials. Drugs
or imaging agents can be easily conjugated chemically to the nanoparticles
to improve the stability of the drug in the nanocarriers. Nanoparticles can
incorporate more than one kind of imaging or therapeutic agents, making them
potential multifunctional systems for both medical diagnosis and therapy. Specific
targeting of tissues and organs can be realized with multiple targeting agents
connected to the nanoparticle surface, providing strength of target binding as
well as high specificity for the target. Many methods of surface modification
have been developed to improve the circulation time of nanoparticles and to
prevent their uptake and removal by the reticuloendothelial system. The use of
nanomaterials as carriers is also stimulated by the potential for improved drug
stability, solubility, and bioavailability, improved pharmacokinetics, and reduced
immunogenicity.
This book results from the symposium Nanomaterials for Biological, Pharmaceutical and Biomedical Applications held at the 240th ACS National Meeting in Boston, MA on August 22-26, 2010. The symposium was sponsored by the ACS Division of Colloid and Surface Chemistry as part of its continuing symposia series on nanoscience and nanotechnology.
Published: 2013-03-22 -- ISBN: 0841227187 -- PDF -- 344 pages -- 18 MB
Download
*