Therapeutic Micro-Nano Technology BioMEMs - Tejlal Desai & Sangeeta Bhatia
Preface
The human body is composed of structures organized in a hierarchical fashion: from
biomolecules assembled into polymers, to multimeric assemblies such as cellular organelles,
to individual cells, to tissues, to organ systems working together in health and
disease- each dominated by a characteristic length scale. Decades of science and engineering
are now converging to provide tools that enable the orderly manipulation of biological
systems at previously inaccessible, though critically important, length scales (
Thus, the approaches described in this volume provide a snapshot of how microand
nanotechnologies can enable the investigation, prevention, and treatment of human
disease.
The volume is divided into three parts. The first part, Cell-based therapeutics;covers
the merger of cells with micro- and nanosystems for applications in regenerative
medicine spanning the development of novel nanobiomaterials, methods of tissue assembly
with control over tissue microarchitecture, and methods to specify patterns of protein
distribution that vary on the micro- and nanoscale for application in tissue regeneration
(A), and therapeutic applications of integrating MEMS with cells and tissues including
label-free microfluidic sorting of cells based on their function, using living cell
arrays as biosensors, and micron-scale devices for surgical applications (B). The second
part, Drug Delivery; covers intravascular delivery of nanoparticles such as semiconductor
quantum dots and metal nanoshells in the context of vascular specialization
or ‘zip codes’ (A) as well as non-vascular modes of delivery including implantation,
oral, and inhalation using both encapsulated drugs as well as living cells that produce
therapeutic products (B). Finally, the third part, Molecular Surface Engineering for the
Biological Interface; covers platforms that provide enabling tools for fundamental investigations
of cells in culture as they interact with biomolecular structures such as responsive
biomaterials and lipid bilayers (A) as well as micropatterned adhesive and fluidic
environments (B).
We would like to thank the contributing authors, our co-editors in this exciting compilation
of volumes, and Dr. Mauro Ferrari for his tireless efforts to lead this endeavor.
We hope the collected works will provide an excellent reference for an audience with a
diversity of background and interests including industry, students, academic researchers,
policy-makers, and enthusiasts.
Download
*
Preface
The human body is composed of structures organized in a hierarchical fashion: from
biomolecules assembled into polymers, to multimeric assemblies such as cellular organelles,
to individual cells, to tissues, to organ systems working together in health and
disease- each dominated by a characteristic length scale. Decades of science and engineering
are now converging to provide tools that enable the orderly manipulation of biological
systems at previously inaccessible, though critically important, length scales (
Thus, the approaches described in this volume provide a snapshot of how microand
nanotechnologies can enable the investigation, prevention, and treatment of human
disease.
The volume is divided into three parts. The first part, Cell-based therapeutics;covers
the merger of cells with micro- and nanosystems for applications in regenerative
medicine spanning the development of novel nanobiomaterials, methods of tissue assembly
with control over tissue microarchitecture, and methods to specify patterns of protein
distribution that vary on the micro- and nanoscale for application in tissue regeneration
(A), and therapeutic applications of integrating MEMS with cells and tissues including
label-free microfluidic sorting of cells based on their function, using living cell
arrays as biosensors, and micron-scale devices for surgical applications (B). The second
part, Drug Delivery; covers intravascular delivery of nanoparticles such as semiconductor
quantum dots and metal nanoshells in the context of vascular specialization
or ‘zip codes’ (A) as well as non-vascular modes of delivery including implantation,
oral, and inhalation using both encapsulated drugs as well as living cells that produce
therapeutic products (B). Finally, the third part, Molecular Surface Engineering for the
Biological Interface; covers platforms that provide enabling tools for fundamental investigations
of cells in culture as they interact with biomolecular structures such as responsive
biomaterials and lipid bilayers (A) as well as micropatterned adhesive and fluidic
environments (B).
We would like to thank the contributing authors, our co-editors in this exciting compilation
of volumes, and Dr. Mauro Ferrari for his tireless efforts to lead this endeavor.
We hope the collected works will provide an excellent reference for an audience with a
diversity of background and interests including industry, students, academic researchers,
policy-makers, and enthusiasts.
Download
*