The Physics of Coronory Blood Flow - M. Zamir
Series Preface
The fields of biological and medical physics and biomedical engineering are
broad, multidisciplinary and dyanmic. They lie at the crossroads of frontier research
in physics, biology, chemistry, and medicine. The Biological & Medical
Physics/Biomedical Engineering Series is intended to be comprehensive,
covering a broad range of topics important to the study of the physical, chemical
and biological sciences. Its goal is to provide scientists and engineers with
textbooks, monographs, and reference works to address the growing need for
information.
Books in the series emphasize established and emergent areas of science including
molecular, membrane, and mathematical biophysics; photosynthetic energy
harvesting and conversion; information processing; physical principles of
genetics; sensory communications; automata networks, neural networks, and
cellular automata. Equally important will be coverage of applied aspects of biological
and medical physics and biomedical engineering such as molecular electronic
components and devices, biosensors, medicine, imaging, physical principles
of renewable energy production, advanced prostheses, and environmental
control and engineering.
Elias Greenbaum
Oak Ridge, TN
Preface
Coronary blood flow is blood flow to the heart for its own metabolic needs.
In the most common form of heart disease there is a disruption in this flow
because of obstructive disease in the vessels that carry the flow. The subject of
coronary blood flow is therefore associated mostly with the pathophysiology
of this disease, rarely with dynamics or physics. Yet, the system responsible
for coronary blood flow, namely the “coronary circulation,” is a highly sophisticated
dynamical system in which the dynamics and physics of the flow are
as important as the integrity of the conducting vessels. While an obstruction
in the conducting vessels is a fairly obvious and clearly visible cause of disruption
in coronary blood flow, any discord in the complex dynamics of the
system can cause an equally grave, though less conspicuous, disruption in the
flow.
This book is devoted specifically to the dynamics and physics of coronary
blood flow. While it upholds the clinical and pathophysiological issues
involved, the book focuses on dynamics and physics, approaching the subject
from a strictly biomedical engineering viewpoint. The rationale for this
approach is simply that the coronary circulation involves many issues in dynamics
and physics, as the book will demonstrate. Also, with this particular
focus, the book will complement other books on the subject, that have so far
focused largely on clinical and pathophysiological issues.
A study of the dynamics of the coronary circulation requires far more
information about the system than is currently available. Whether in terms
of anatomical details of the vasculature, system properties such as capacitance
and elasticity of the conducting vessels, or the basic and regulatory conditions
under which the system operates, the information currently available is highly
incomplete. Thus, the scope of this book is limited to dynamical aspects of
coronary blood flow, but within these limits it is also constrained to deal
necessarily with an incomplete picture of these dynamics. In particular, the
book does not include the microcirculation, the venous part of the coronary
circulation, Thebesian veins or the lymphatic system. Also, the many-faceted
regulatory mechanisms of the coronary circulation are not considered in any
systematic or factual way, but only tangentially in how they may affect the
dynamics of the system. These omissions reflect the degree of complexity of
the coronary circulation and serve as a sober reminder that it may never be
possible or practical to deal with this complexity in a single book.
Download
http://s18.alxa.net/s18/srvs2/02/003...ow-M.Zamir.rar
Series Preface
The fields of biological and medical physics and biomedical engineering are
broad, multidisciplinary and dyanmic. They lie at the crossroads of frontier research
in physics, biology, chemistry, and medicine. The Biological & Medical
Physics/Biomedical Engineering Series is intended to be comprehensive,
covering a broad range of topics important to the study of the physical, chemical
and biological sciences. Its goal is to provide scientists and engineers with
textbooks, monographs, and reference works to address the growing need for
information.
Books in the series emphasize established and emergent areas of science including
molecular, membrane, and mathematical biophysics; photosynthetic energy
harvesting and conversion; information processing; physical principles of
genetics; sensory communications; automata networks, neural networks, and
cellular automata. Equally important will be coverage of applied aspects of biological
and medical physics and biomedical engineering such as molecular electronic
components and devices, biosensors, medicine, imaging, physical principles
of renewable energy production, advanced prostheses, and environmental
control and engineering.
Elias Greenbaum
Oak Ridge, TN
Preface
Coronary blood flow is blood flow to the heart for its own metabolic needs.
In the most common form of heart disease there is a disruption in this flow
because of obstructive disease in the vessels that carry the flow. The subject of
coronary blood flow is therefore associated mostly with the pathophysiology
of this disease, rarely with dynamics or physics. Yet, the system responsible
for coronary blood flow, namely the “coronary circulation,” is a highly sophisticated
dynamical system in which the dynamics and physics of the flow are
as important as the integrity of the conducting vessels. While an obstruction
in the conducting vessels is a fairly obvious and clearly visible cause of disruption
in coronary blood flow, any discord in the complex dynamics of the
system can cause an equally grave, though less conspicuous, disruption in the
flow.
This book is devoted specifically to the dynamics and physics of coronary
blood flow. While it upholds the clinical and pathophysiological issues
involved, the book focuses on dynamics and physics, approaching the subject
from a strictly biomedical engineering viewpoint. The rationale for this
approach is simply that the coronary circulation involves many issues in dynamics
and physics, as the book will demonstrate. Also, with this particular
focus, the book will complement other books on the subject, that have so far
focused largely on clinical and pathophysiological issues.
A study of the dynamics of the coronary circulation requires far more
information about the system than is currently available. Whether in terms
of anatomical details of the vasculature, system properties such as capacitance
and elasticity of the conducting vessels, or the basic and regulatory conditions
under which the system operates, the information currently available is highly
incomplete. Thus, the scope of this book is limited to dynamical aspects of
coronary blood flow, but within these limits it is also constrained to deal
necessarily with an incomplete picture of these dynamics. In particular, the
book does not include the microcirculation, the venous part of the coronary
circulation, Thebesian veins or the lymphatic system. Also, the many-faceted
regulatory mechanisms of the coronary circulation are not considered in any
systematic or factual way, but only tangentially in how they may affect the
dynamics of the system. These omissions reflect the degree of complexity of
the coronary circulation and serve as a sober reminder that it may never be
possible or practical to deal with this complexity in a single book.
Download
http://s18.alxa.net/s18/srvs2/02/003...ow-M.Zamir.rar